Hydrophobic Interaction Chromatography Market Size, Share, Competitive Landscape and Trend Analysis Report, by Product and Service, by Sample type, by Application, by End user : Global Opportunity Analysis and Industry Forecast, 2024-2033

Hydrophobic Interaction Chromatography Market Research, 2033

The global hydrophobic interaction chromatography market was valued at $461.9 million in 2023, and is projected to reach $952.9 million by 2033, growing at a CAGR of 7.5% from 2024 to 2033. The hydrophobic interaction chromatography market growth is driven by an increase in demand for biopharmaceuticals, advancements in purification technologies, and rise in R&D investments in biotechnology. The method's efficiency in separating and purifying proteins boosts its adoption. In addition, regulatory support for biologics production fuels market growth.

Hydrophobic interaction chromatography (HIC) is a purification technique used to separate biomolecules based on their hydrophobicity. It exploits the natural tendency of nonpolar molecules to associate in aqueous environments. In HIC, samples are introduced into a column containing a hydrophobic stationary phase, typically composed of ligands such as butyl, octyl, or phenyl groups attached to a solid support. The process begins with a high-salt buffer, promoting hydrophobic interactions between the target molecules and the stationary phase. As the salt concentration is gradually reduced, less hydrophobic molecules are removed first, while more hydrophobic molecules remain bound longer.

Key Takeaways

• By product and service, the product segment dominated the global market in terms of revenue in 2023 and is expected to register the highest CAGR during the forecast period.
• By sample type, the monoclonal antibodies segment was the largest contributor to the market in 2023 and is expected to register the highest CAGR during the forecast period.
• By application, the protein and antibody purification segment was the largest contributor to the market in 2023 and is also expected to register the highest CAGR during the forecast period.
• By end user, the pharmaceutical and biopharmaceutical companies segment dominated the market in 2023. However, the contract research organizations and contract manufacturing organizations segment is expected to grow at a CAGR during the forecast period.
• By region, North America dominated the hydrophobic interaction chromatography market share in terms of revenue in 2023. However, Asia-Pacific is expected to register the highest CAGR during the forecast period.

Market Dynamics

The hydrophobic interaction chromatography market growth has experienced significant growth, driven by several key factors in the biotechnology, pharmaceutical, and life sciences sectors. One of the primary drivers is the increase in demand for biopharmaceuticals, including monoclonal antibodies, vaccines, and therapeutic proteins. These complex biomolecules require advanced purification techniques such as HIC to ensure high purity and functionality, particularly in large-scale production processes. As the biopharmaceutical industry continues to expand, especially with the rise of personalized medicine and biologics, the need for efficient and scalable purification methods has become crucial, thus propelling the growth of the HIC market.

In addition, advancements in HIC technologies contribute to market expansion. Innovations in stationary phases, such as improved resin formulations with better selectivity and binding capacities, enhance the efficiency and effectiveness of HIC. These advancements enable better separation of biomolecules, reduce processing times, and minimize the loss of active compounds, making HIC more attractive for large-scale applications. Furthermore, the development of new techniques, such as multistep or mixed-mode chromatography, that combine HIC with other methods to improve resolution and throughput, is expanding its applications in research and commercial production, thereby driving hydrophobic interaction chromatography market opportunity.

However, the high cost associated with HIC resin materials and the overall chromatography process limits the adoption of HIC and restricts market growth. The specialized equipment, reagents, and resins required for HIC can be expensive, making it a costly option for some laboratories and smaller companies, especially in developing regions. In addition, the complexity of method development and optimization for different biomolecules requires significant time and expertise, which may limit its widespread adoption. Furthermore, the need for highly skilled personnel to operate and manage HIC systems also add to operational costs and thereby hinders market growth.

On the other hand, the increasing demand for monoclonal antibodies, therapeutic proteins, and biosimilars provides an opportunity for market growth. As these biologics require high-purity purification, HIC is becoming an essential tool for effective protein and antibody isolation, presenting ample growth prospects. Technological advancements in chromatography resins and the development of more efficient, cost-effective HIC systems also present opportunities for the market to expand, as these innovations make HIC more accessible and scalable for commercial production. Moreover, the growing emphasis on improving manufacturing processes and regulatory compliance in the pharmaceutical industry creates a favorable environment for HIC adoption, as it meets stringent quality standards for protein production, thus boosting hydrophobic interaction chromatography market forecast.

Segments Overview

The hydrophobic interaction chromatography market is segmented on the basis of product & service, sample type, application, end user, and region. On the basis of product and service, the market is classified into product and service. The product segment is further categorized into resin, buffer, column, and others. The resin segment is further classified into beads and others. The column segment is further divided into pre-packed columns and empty columns. The pre-packed column segment is further categorized into disposable and reusable.

On the basis of sample type, the market is classified into monoclonal antibodies, vaccines, cell culture sample, plasma and serum sample, and others. On the basis of application, the market is segmented into protein & antibody purification, vaccine development, drug discovery, and food & dietary supplement development. On the basis of end user, the market is segmented into pharmaceutical & biopharmaceutical companies, contract research organizations & contract manufacturing organizations, research & academic institutes, and others. Region wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.

By Product and Service

The product segment dominated the market share in 2023 and is anticipated to register the fastest CAGR growth during the forecast period. This is attributed to the rise in demand for biologics, including monoclonal antibodies and therapeutic proteins. The increasing adoption of HIC for large-scale protein purification in the biopharmaceutical industry is a key factor. In addition, continuous advancements in chromatography resins and purification technologies further contribute to the growth of this segment.

 PRODUCTANDSERVICEGRAPH]

By Sample Type 

The monoclonal antibodies segment dominated the market share in 2023 and is anticipated to register the fastest CAGR growth during the forecast period. This is attributed to their increase in use in the treatment of cancer, autoimmune diseases, and other chronic conditions. The growing demand for targeted therapies and personalized medicine is driving this trend. In addition, advancements in monoclonal antibody production and purification technologies, including hydrophobic interaction chromatography, further support market growth.

By Application

The protein and antibody purification segment held the largest hydrophobic interaction chromatography market share in 2023 and is anticipated to register the fastest CAGR growth during the forecast period. This is attributed to the rise in demand for high-purity proteins and antibodies in drug development and therapeutic applications. The increasing focus on biologics and biosimilars, coupled with the need for efficient and scalable purification methods, drives the adoption of HIC. In addition, advancements in chromatography techniques that enhance protein stability and yield further contribute to the growth of this segment.

By End User

The pharmaceutical & biopharmaceutical companies segment held the largest hydrophobic interaction chromatography market size in 2023. This is attributed to the rise in demand for high-purity proteins and antibodies in drug development and therapeutic applications. The increasing focus on biologics and biosimilars, coupled with the need for efficient and scalable purification methods, drives the adoption of HIC. In addition, advancements in chromatography techniques that enhance protein stability and yield further contribute to the growth of this segment.

However, the contract research organizations and contract manufacturing organizations development segment is expected to register the highest CAGR during the forecast period. This is attributed to the increase in outsourcing of drug development and manufacturing processes to CROs and CMOs, which require efficient and scalable purification techniques such as HIC. In addition, the ability of CROs and CMOs to leverage advanced HIC technologies for large-scale protein and antibody purification further fuels the segment growth.

By Region

The hydrophobic interaction chromatography industry is analyzed across North America, Europe, Asia-Pacific, and LAMEA. North America dominated the market hydrophobic interaction chromatography market size in 2023. This dominance is attributed to the presence of a well-established biopharmaceutical industry, which heavily relies on advanced purification techniques such as HIC for the production of monoclonal antibodies, therapeutic proteins, and other biologics. The region benefits from significant investments in research and development, particularly in the fields of biotechnology and pharmaceuticals.

However, the Asia-Pacific region is anticipated to register the highest CAGR during the forecast period. This is attributed to the biotechnology and pharmaceutical industries in countries like China, India, and Japan, where there is an increasing demand for biologics and biosimilars. The region's expanding contract research and manufacturing services, coupled with rising investments in healthcare infrastructure, are driving the adoption of advanced purification technologies like hydrophobic interaction chromatography (HIC). In addition, favorable government policies, lower production costs, and the growing focus on improving research and development capabilities in the life sciences sector contribute to the region's strong market potential.

Competitive Analysis

Key players such as Waters Corporation and Merck KGaA. have adopted expansion product launch, and partnership as key developmental strategies to improve the product portfolio of the hydrophobic interaction chromatography market. For instance, in June 2023, Merck, a leading science and technology company expanding production capacity for highly purified reagents at its site in Nantong, China.

Recent Development in the Hydrophobic Interaction Chromatography Industry

• In June 2022, Bio-Rad Laboratories, Inc. announced the launch of EconoFit Low-Pressure Prepacked Chromatography Column Packs to support resin screening experiments in the development of protein purification workflows.
• In September 2024, the PPD clinical research business of Thermo Fisher Scientific, the world leader in serving science, announced the expansion of its global laboratory services with a new bioanalytical lab in GoCo Health Innovation City in Gothenburg, Sweden, that will serve pharmaceutical and biotech customers with advanced laboratory services and leading-edge instrumentation across all phases of pharmaceutical development to help deliver life-changing medicines to patients worldwide. 
• In October 2024, Tosoh Bioscience announced the grand opening of its expanded European Tosoh Bioscience headquarters in Griesheim, Germany. This significant milestone marks a new chapter in the commitment of Tosoh to biomolecule analysis, purification, and polymer analytical technologies. This new facility will allow us to better serve customers and explore new chromatography techniques and applications.

Key Benefits For Stakeholders

• This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the hydrophobic interaction chromatography market analysis from 2023 to 2033 to identify the prevailing hydrophobic interaction chromatography market opportunities.
• The market research is offered along with information related to key drivers, restraints, and opportunities.
• Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
• In-depth analysis of the hydrophobic interaction chromatography market segmentation assists to determine the prevailing market opportunities.
• Major countries in each region are mapped according to their revenue contribution to the global market.
• Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
• The report includes the analysis of the regional as well as global hydrophobic interaction chromatography market trends, key players, market segments, application areas, and market growth strategies.

  Hydrophobic Interaction Chromatography Market Report Highlights

Aspects	Details
Market Size By 2033	USD 952.9 million
Growth Rate	CAGR of 7.5%
Forecast period	2023 - 2033
Report Pages	412
By Product and Service	Product Type Resin Type Beads Others Buffer Column Type Pre packed Columns Others Service
By Sample type	Monoclonal antibodies Vaccines Cell culture sample Plasma and serum sample Others
By Application	Protein and antibody purification Resins Beads Others Vaccine development Drug discovery Food and dietary supplement development
By End user	Research and academic institutes Others Pharmaceutical and biopharmaceutical companies Contract research organizations and contract manufacturing organizations
By Region	North America  (U.S., Canada, Mexico) Europe  (Germany, France, UK, Italy, Spain, Rest of Europe) Asia-Pacific  (Japan, China, India, Australia, South Korea, Rest of Asia-Pacific) LAMEA  (Brazil, South Africa,, Saudi Arabia, Rest of LAMEA)
Key Market Players	Sepax Technologies, Inc., Thermo Fisher Scientific Inc., Danaher Corporation, KNAUER Wissenschaftliche Gerate GmbH, Geno Technology, Inc., Merck KGaA, Waters Corporation, Agilent Technologies, Inc., Bio-Rad Laboratories, Inc. , Tosoh Corporation, Sartorius AG

Analyst Review

This section provides various opinions of top-level CXOs in the global hydrophobic interaction chromatography market. According to the insights of CXOs, the global hydrophobic interaction chromatography market is expected to exhibit high growth potential attributable to increase in demand for biologics, monoclonal antibodies, and therapeutic proteins. Advancements in biotechnology and pharmaceutical research, particularly in protein purification technologies, drive the adoption of hydrophobic interaction chromatography (HIC). 

CXOs further added that the rise in prevalence of chronic diseases, along with a shift toward personalized medicine, further fuels the need for efficient and high-purity drug production methods, thereby driving the adoption of HIC techniques. In addition, continuous improvements in HIC technologies, such as enhanced resin formulations and automation, have made the process more cost-effective and scalable. Strong government investments in the biopharmaceutical industry and a rise in emphasis on regulatory compliance contribute to market expansion. 

Furthermore, North America dominated the market share, in terms of revenue in 2023, owing to advanced healthcare infrastructure and high demand for biologics and therapeutic proteins. In addition, stringent regulatory requirements drive the adoption of hydrophobic interaction chromatography for high-purity production. However, Asia-Pacific is anticipated to witness notable growth owing to a rapid advancement in biotechnology & pharmaceutical manufacturing, increased investments in biomanufacturing infrastructure, and rise in demand for biologics & therapeutic proteins.
 

Author Name(s) : Shraddha Mali | Roshan Deshmukh

Related Tags

• Hydrophobic Interaction Chromatography