Chromatography Resins Market Expected to Reach $4.1 Billion by 2030

According to a new report published by Allied Market Research, titled, "chromatography resins market by type and application: global opportunity analysis and industry forecast, 2021–2030," the global chromatography resins market was valued at $2.1 billion in 2020, and is projected to reach $4.1 billion by 2030, growing at a CAGR of 7.1% from 2021 to 2030.

The global chromatography resins market forecast was valued at $2.1 billion in 2020, and is projected to reach $4.1 billion by 2030, growing at a CAGR of 7.1% from 2021 to 2030.

Chromatography resins are medias that are made up of cellulosic matrix. These resins find application in protein purification, biomolecule separation & purification, and vaccine production & purification. 

The growth of the global chromatography resins market is driven by increasing use of chromatographic resins in biomolecule separation and vaccine production. Affinity chromatography resins, mixed mode resins, ion exchange resins, hydrophobic interaction resins, size exclusion resins, and hydroxyapatite resins are commonly used during biomolecule separation and purification process. Chromatography resins are used for capturing, separation, and purification of biomolecules. Mixed mode chromatography resins are viable and widely adopted chromatography resins for biomolecule purification as other types of resin find difficulties during separation and purification of biomolecules. Chromatography industry is gaining importance including mixed mode chromatography resins for biomolecule production and purification process. Coupled with advantages such as robustness and enhanced productivity of mixed mode chromatography resins makes them widely used resins during biomolecule purification techniques. Interaction specificity and strength are two primary factors considerable in order for chromatography resins for biomolecule purification process. 

On the contrary, ion-exchange chromatography technique is widely used during industrial and municipal water treatment. However, fouling of compounds such as calcium sulfate & iron, occurrence of organic matter adsorption and contamination due to resins are factors that are hampering the market growth. 

Desalting chromatography technique is simple and proven laboratory scale technique for removal of low molecular weight impurities. This technique requires use of desalting resins owing to its ability to remove and simultaneously transfer trial into the chosen buffer pool in a single step. Thus, use of desalting resins in laboratory scale chromatography technique is the key market trend. Immunoprecipitation chromatography technique is effective antigens separation method from crude cell lysates. Thus, use of immunoprecipitation resins for such application is driving the demand of the global market. Use of IEX resins during high-resolution protein separation application owing to its maximum sample loading capacity is the key market trend. Other application of IEX resins includes purification of viruses and plasmid DNA owing to its high binding capacity over wide range of pH and conductivity conditions. Moreover, these resins enhance process advancement flexibility and industrial throughput. This factor is anticipated to offer new opportunities during the forecast period.

The chromatography resins market is segmented on the basis of type, application, and region. On the basis of type, the market is categorized into hydrophobic interaction resin, multimodal or mixed-mode resin, size exclusion resin, affinity resin, ion-exchange resin, and others. By application, the market is divided into antibody purification, biomolecule separation & purifications, vaccination, and others. Region wise, the market is studied across North America, Europe, Asia-Pacific, and LAMEA.

The global chromatography resins market profiles leading players that include Cytiva Lifesciences, Bio-Rad Laboratories Inc., Sartorius AG, Generon, Tosoh Bioscience, Bio-Works, Repligen Corporation, LAF-Biotechnology, JNC Corporation, Anatrace Products LLC.

The global chromatography resins market report provides in-depth competitive analysis as well as profiles of these major players.

COVID-19 analysis

The novel coronavirus is an incomparable global pandemic that has spread to over 180 countries and caused huge losses of lives and the economy around the globe. The chromatography resins market has been positively impacted due to the wake of the COVID-19 pandemic, owing to its dependence on biomolecule separation & purifications, vaccination, and protein separation application. Protein A derived chromatography resins are employed to overcome purification challenges that occur during development of coronavirus vaccines. For instance, Navigo and Repligen team have developed affinity resins that are used downstream processing (DSP) owing to its ability to escalate the purification speed and yield high quality COVID-19 vaccine. Navigo has developed protein a affinity resins that are developed or captured using spike protein from coronavirus. In addition, Repligen will offer chromatography beads that in turn enhances generation of high quality spike protein A affinity resins. 

COVID-19 vaccines are based on recombinant protein and production involves several challenges in DSP process. For instance, low concentration and high background capacity of host cell proteins make these vaccine production and purification a time consuming and high cost production steps. In addition, primary DSP steps includes chronological chromatography steps, manufacturers need to handle large volumes of liquid, and every protein vaccine requires newly developed-from-scratch DSP. Thus, to overcome these problems, vaccine manufacturers are following affinity chromatography techniques which in turn is escalating the demand of chromatographic resins amid COVID-19 pandemic.

Affinity chromatographic resins are capable of binding and isolating target protein vaccine proficiently from insipid and compound liquid mixtures. Moreover, other types of COVID-19 vaccines such as m-RNA based those are under development by Curevac, BioNtech, and Moderna are employing affinity resins during production of vaccines. All these factors are driving the demand of the global market despite of ongoing COVID-19 pandemic. Apart from vaccine production, chromatography finds its application during understanding and production of diagnostic tools that are utmost important to curb the spread of virus.

This is another considerable factor driving the demand of global market in the pandemic situation. Apart from vaccine production, chromatography technique is also employed to test COVID-19 infection through breath test. Growing demand for accuracy and swift recognition of COVID-19 infection in patients is growing which in turn escalating the demand and production of chromatographic resins. At early stage of COVID-19 pandemic, tests used to be carried out in laboratories. This process is time consuming, involves high cost, and requires resources. Thus, to overcome these problems, several research and development activities are carried and developed rapid diagnosis using gas chromatography-ion mobility spectrometry technique. All these factors have positively impacted on the growth of global chromatography resins market.

Key findings of the study

• The ion-exchange chromatography resins type is estimated to display highest growth rate, in terms of revenue, registering a CAGR of 7.5% from 2021 to 2030.
• The antibody purification application is anticipated to register highest CAGR of 7.4% during the forecast period.
• North America garnered highest share of 34.3% in 2020, in terms of revenue, growing at a CAGR of 7.6% during the forecast period.