Downstream Processing Market Expected to Reach $92.0 Billion by 2030—Allied Market Research

According to a new report published by Allied Market Research, titled, “Downstream Processing Market," The Downstream Processing Market Size at $21.8 billion in 2020, and is estimated to reach $92.0 billion by 2030, growing at a CAGR of 13.5% from 2021 to 2030.

Downstream processing involves the process of purification and recovery of biosynthetic products, which includes mainly pharmaceuticals and are obtained from the natural sources. Downstream processing consists of five stages that include solid-liquid separation, intracellular products are released, and concentration and chromatography method is used for purification and formulation. The separation method includes methods such as flocculation, centrifugation flotation, and filtration.

Rise in demand for single-use systems, lower risk of cross-contamination and reduced manufacturing costs and increase in demand for biopharmaceuticals drive the Downstream Processing Market Growth. In addition, the increase in the prevalence of chronic disease such as cancer, genetic disorders, and rare disease among others and COVID-19 pandemic has increased the demand for vaccines and antibody production, which is expected to drive the growth of the market in upcoming years. However, dearth and shortage of skilled bioprocess engineers restrain the market growth. Moreover, emerging markets such as China and India, offer profitable opportunities to expand this market.

The Downstream Processing Market Analysis on the basis of technique, product, system, application, end user, and region. By technique, it is categorized into purification, separation, and clarification/concentration. Depending on product, it is classified into chromatography columns and resins, filters, membrane adsorbers, and other products.

By system, it is bifurcated into single use system and re-usable system. By application, it is divided into monoclonal antibody production, vaccine production, insulin production, immunoglobulin production, erythropoietin production, and other applications. By end user, it is categorized into biopharmaceutical manufacturers, and contract manufacturing organizations (CMOs). Region wise, the market is analyzed across North America (the U.S., Canada, and Mexico), Europe (Germany, France, the UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).

By technique, the purification segment generated the highest revenue in the downstream processing market in 2020 owing to rise in demand for monoclonal antibodies due to rise in the cases of cancer and increase in adoption of biopharmaceuticals across the world. By product, the chromatography columns and resins segment generated the highest revenue in the downstream processing market in 2020, owing to increasing demand for therapeutic antibodies, public-private investment in pharmaceutical & life science research as well as constant need for newer and different types of columns and resins.

By system, the single use system segment generated the highest revenue in the downstream processing market in 2020, owing to reduction in bioprocessing time, increase in downstream processing annual output and reduced operational costs while using single-use segments. By application, the monoclonal antibody production segment generated the highest revenue in the downstream processing market in 2020, owing to prevalence of cancer, rise in regulatory approvals and launch of therapies for cancer treatment. By end user, the biopharmaceutical manufacturers segment generated the highest revenue in the downstream processing market in 2020, owing to increasing demand for biopharmaceuticals among the aging population.

By region, North America accounted for largest Downstream Processing Market Share in 2020 and is expected to retain its dominance throughout the forecast period. This is primarily attributed to increase in R&D activities for biopharmaceuticals, considerable investments made by the market players and increase in government support.

Asia-Pacific witnessed the highest growth rate for the downstream processing market and is expected to continue this trend throughout the forecast period, which is attributed to rise in expenditure on healthcare and improvement in the medical and healthcare infrastructure. In addition, the key market players focus on opportunities offered by the growing demand for single-use systems in the downstream process. This system is highly cost-effective, which has gained popularity among end users. Moreover, significant growth of the pharmaceutical and biotechnology industries supplements the market growth.

KEY FINDINGS OF THE STUDY

• On the basis of technique, the purification segment held 43.98% share in the global Downstream Processing Industry in 2020.
• On the basis of product, the chromatography columns and resins segment held the largest Downstream Processing Market Size in 2020, and is expected to remain dominant throughout the forecast period.
• According to the application, the monoclonal antibody production segment exhibits the largest Downstream Processing Industryshare in 2020, and is expected to remain dominant throughout the forecast period.
• On the basis of end-user, the biopharmaceutical manufacturers segment held the largest market share in 2020, and is expected to remain dominant throughout the forecast period.
• Region-wise, North America is expected to experience the highest market share during the forecast period. This was attributed to an increase in R&D activities for biopharmaceuticals, considerable investments made by the market players and increase in government support.