Hydrophobic Interaction Chromatography Market Expected to Reach $952.9 Million by 2033

According to a new report published by Allied Market Research, titled, “Hydrophobic Interaction Chromatography Market," The hydrophobic interaction chromatography market was valued at $461.89 million in 2023, and is estimated to reach $952.9 million by 2033, growing at a CAGR of 7.5% from 2024 to 2033.

The major factors which drive the global hydrophobic interaction chromatography market growth are surge in demand for biologics and monoclonal antibodies, which require advanced purification techniques for their production. As the prevalence of chronic diseases continues to rise, the need for biologic drugs, such as therapeutic proteins and vaccines, has significantly increased, spurring the adoption of HIC as an efficient method for protein purification. In addition, the rapid growth of the biopharmaceutical industry, fueled by advancements in biotechnology and increase in focus on personalized medicine, contributes to market expansion. The development of new biologic drugs, coupled with rise in investments in R&D, particularly in emerging markets, further drives the demand for HIC technologies.

For instance, a 2021 study published by the National Library of Medicine focused on the development of the recombinant protein antigen RBD219-N1C1, derived from the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, formulated with Alhydrogel to trigger a strong neutralizing antibody response. The study compared three chromatographic methods hydrophobic interaction chromatography (HIC), anion-exchange chromatography (AEX), and cation-exchange chromatography (CEX)for optimizing both upstream fermentation and downstream purification processes. Hydrophobic interaction chromatography (HIC) was used using a butyl HP column and 1 M ammonium sulfate for binding. After HIC, 67% of the target protein was recovered, and purity significantly improved from 85.6% in the fermentation supernatant to 97.6%. This highlights the efficiency of HIC in enhancing protein purity and recovery, making it a valuable tool in biologic drug development processes thereby propelling the hydrophobic interaction chromatography market growth. 

However, the complexity of HIC techniques, which require skilled personnel and extensive training, hinders its widespread use in some regions. The need for continuous innovation to keep up with evolving regulatory standards and the high capital investment required for large-scale biomanufacturing hinder market growth. In addition, the availability of alternative purification techniques, such as ion exchange chromatography and affinity chromatography, which are preferred in certain applications, could restrict the widespread adoption of HIC. On the other hand, the expansion of the biopharmaceutical industries in emerging markets, along with government funding and initiatives aimed at boosting biomanufacturing infrastructure, create new hydrophobic interaction chromatography market opportunity for market penetration. 

The hydrophobic interaction chromatography market analysis is segmented on the basis of product & service, sample type, application, end user, and region. Depending on the product and service, the market is classified into product and service. The product segment is further classified into resin, buffer, column, and others. The product segment dominated the market share in 2023 and is expected to register the highest CAGR during the forecast period. This is attributed to the increase in demand for advanced chromatography resins, which are crucial for the efficient purification of biologics, monoclonal antibodies, and therapeutic proteins.

As the biopharmaceutical industry continues to grow, the need for high-quality, scalable, and cost-effective purification solutions drives the demand for innovative products in the chromatography space. Furthermore, advancements in chromatography resins, such as improved performance, higher capacity, and better reproducibility, enhance the adoption of these products in protein purification processes, thereby boosting the hydrophobic interaction chromatography market forecast.

Depending on sample type, the market is classified into monoclonal antibodies, vaccines, cell culture sample, plasma and serum sample, and others. The monoclonal antibodies segment dominated market share in 2023 and is expected to register the highest CAGR during the forecast period. This is attributed to the rise in demand for monoclonal antibodies in the treatment of various chronic diseases, including cancer, autoimmune disorders, and infectious diseases. Monoclonal antibodies are key biologic drugs requiring advanced purification methods, such as hydrophobic interaction chromatography (HIC), for high-purity production. Increase in prevalence of chronic diseases and shift toward personalized medicine significantly boost the demand for these monoclonal antibodies, and are also the the hydrophobic interaction chromatography market trends.

Depending on application, the market is segmented into protein & antibody purification, vaccine development, drug discovery, and food & dietary supplement development. The protein and antibody purification segment dominated the hydrophobic interaction chromatography market share in 2023 and is expected to register the highest CAGR during the forecast period. This is attributed to an increase in demand for high-purity proteins and antibodies used in therapeutic treatments, diagnostics, and research. The surge in prevalence of chronic diseases, cancer, & autoimmune disorders, and rise in focus on personalized medicine boost the need for efficient and reliable protein and antibody purification methods.

Depending on end user, the market is segmented into pharmaceutical & biopharmaceutical companies, contract research organizations & contract manufacturing organizations, research & academic institutes, and others. The pharmaceutical and biopharmaceutical companies segment dominated the hydrophobic interaction chromatography market size in 2023. This was attributed to the increasing demand for biologics, such as monoclonal antibodies and vaccines. The need for advanced purification methods such as hydrophobic interaction chromatography (HIC) to ensure high-quality production is a key factor that drives the growth of the segment. 

However, contract research organizations and contract manufacturing organizations development segment is expected to register the highest CAGR during the forecast period. This is attributed to the increase in outsourcing of drug development and manufacturing services. Rise in demand for efficient and scalable purification solutions, such as hydrophobic interaction chromatography (HIC), drives segment growth. 

Region wise, North America was the largest hydrophobic interaction chromatography market size shareholder in 2023, owing to its well-established biopharmaceutical sector and high demand for biologics and monoclonal antibodies. The region benefits from substantial investments in biotechnology, research, and development, which enhance the adoption of advanced purification technologies such as hydrophobic interaction chromatography. 

However, Asia-Pacific is anticipated to register the highest CAGR during the forecast period owing to rapid advancements in biotechnology and pharmaceutical manufacturing. The region has witnessed increased investments in biomanufacturing facilities and infrastructure, which boosts the demand for advanced purification technologies such as hydrophobic interaction chromatography. 

Key findings of The study 

• By product and service, the product segment was largest contributor to the hydrophobic interaction chromatography industry in 2023 and is expected to register the highest CAGR during the forecast period.  
• By sample type, the monoclonal antibodies segment is largest contributor to the market in 2023 and is expected to register the highest CAGR during the forecast period. 
• By application, the protein and antibody purification segment largest contributor to the hydrophobic interaction chromatography industry in 2023 and is also expected to register the highest CAGR during the forecast period.
• By end user, the pharmaceutical and biopharmaceutical companies segment dominated the hydrophobic interaction chromatography market share in 2023. However, the contract research organizations and contract manufacturing organizations segment is expected to grow at a CAGR during the forecast period. 
• Region wise, North America generated the largest revenue in 2023. However, Asia-Pacific is anticipated to grow at the highest CAGR during the forecast period.