Report Code : A17089
The factors that are anticipated to impede the growth of the global nucleic acid therapeutics market during the forecast period include, absence of alternative treatments for a variety of chronic conditions, accessibility of medicines, and high diagnostic costs. The growth of the nucleic acid therapeutics market is driven by increased research & development of new medicines and therapies and increased disease prevalence.
Onkar Sumant - Manager
Life Sciences at Allied Market Research
According to a new report published by Allied Market Research, titled, “Nucleic Acid Therapeutics Market," The nucleic acid therapeutics market was valued at $4.1 billion in 2021, and is estimated to reach $12.2 billion by 2031, growing at a CAGR of 11.6% from 2022 to 2031.
The basic polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) have been extensively studied over the past two decades and are now being considered as stand-alone medicinal agents. Much of the development has resulted from the realization that they perform a wide range of tasks that go beyond simple protein production and genetic information storage. Many of nucleic acid substances have regulatory authorization for usage in humans, and many are currently undergoing clinical trials. Fomivirsen, developed by Ionis Pharmaceuticals in 1998 for the treatment of cytomegalovirus (CMV) retinitis, is the first ASO to be approved for use in humans. The siRNAs are double-stranded molecules with a short length of 21–23 nucleotides, synthesized chemically and are most stable. The global nucleic acid therapeutics market size is to expand as more R&D activities are conducted in an effort to create an effective treatment. the driving factors which are boosting the market during nucleic acid therapeutics market forecast are expanding government programs and investments for the development of innovative gene therapies. Spreading more consciousness about various chronic illnesses will also contribute to global nucleic acid therapeutics market growth. The nucleic acid therapeutics market analysis from 2021 to 2031 to identify the prevailing nucleic acid therapeutics market opportunity.
The nucleic acid therapeutics industry is expected to grow rapidly due to various new therapies in the approval and developmental stages. Furthermore, nucleic acid therapeutics market trends is also to advance due to the expansion of the pharmaceutical, healthcare industries, biological products developments, and DNA-based therapies. On the other hand, lack of expertise, minimum availability of technologies, and high cost of treatment may restrain the expansion of the global nucleic acid therapeutics market size. Furthermore, the need for nucleic acid therapeutics significantly decreased after the COVID-19 pandemic. The focus of medical professionals, governments, and the general public has moved to containing the virus's spread as a result of the fatal virus's quick expansion. It consequently decreased the need for nucleic acid therapies. People visited clinics and hospitals only if they had an emergency, due to which, various other diseases were ignored by the healthcare professionals. As a result, the COVID-19 pandemic caused severe disruptions in the market for diagnosis and treatment of the nucleic acid therapeutics.
Coronavirus Severe acute respiration syndrome (SARS-CoV-2) is an infectious disease caused by the novel coronavirus (COVID-19), which originated in the Wuhan district in China in the late 2019, and since has spread to 212 countries. The virus was initially referred to as “novel coronavirus 2019” (2019-nCoV) by the WHO, However, on February 11, 2020, it was given the official name of SARS-CoV-2 by the International Committee on Taxonomy of Viruses. WHO declared COVID-19 as pandemic on March 11, 2020, and by September 1, 2020, over 28.1 million people have been infected globally with over 909,000 deaths. COVID-19 symptoms include fever, cough, and shortness of breath.
Nearly all industries have been impacted by the global public health pandemic, COVID-19. As coronavirus crises sweep the globe and force healthcare organizations to devote the majority of their funds to fight COVID-19, it has also resulted in a significant decline in demand for the nucleic acid therapeutics market share across several sectors, particularly the health and pharmaceutical sectors. The main cause of the interruptions experienced by patients getting treatment for nucleic acid therapeutics in hospitals was the risk of infection. The treatments based on nucleic acid require hospitalization, hence the market growth declined during this period. As a result, the COVID-19 outbreak slowed down the global market growth for treatments of nucleic acid therapeutics, which was expected to have a negative effect on the market's value in 2020 and beyond.
By products, the anti-sense oligonucleotides (ASOS) and DNA aptamers segment dominated the market in 2021. The factors responsible for the product segment growth are increased in anti-sense oligonucleotides (ASOS) and DNA aptamers product offering and increase in approval of the novel treatments. For instance, Nusinersen was approved by the FDA in 2016 for the treatment of neurological disorders by administration of ASOS intrathecally and Viltepso (Viltolarsen) was approved by FDA and marketed in 2020 for the treatment of muscular dystrophy. Furthermore, increased demand and approval for novel therapies supported the segment growth during forecast period.
Depending on application, monogenetic disorders segment dominated the market in 2021 and is expected to remain dominant during the forecast period. The variation or mutation in the single gene leads to monogenetic disorders. The prevalence of monogenetic disorders is high as it is inherited from parents to newborns. Monogenetic disorders include, cystic fibrosis, muscular dystrophy, sickle cell anemia, marfan syndrome, and others. According to World Health Organization, there are about 5,000 types of monogenetic disorders known till today. Moreover, new therapies are being developed for the treatment of monogenetic disorders.
On the basis of end user, the hospital and clinics segment dominated the market in 2021 and is expected to remain dominant during the forecast period. The market growth of this segment is driven by the increased patient treatments. The nucleic acid therapies are given to the patient in hospitals as these treatments are done by the expert doctors and professional physicians hence the segment generate higher revenue.
Region-wise, in nucleic acid therapeutics industry, North America has the highest market share. North America advances due to availability of treatments, new developing therapies of nucleic acids, and increased monogenetic disease count in the U.S. and Mexico.
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Nucleic Acid Therapeutics Market by Products (Anti-Sense Oligonucleotides (ASOs) and DNA Aptamers, RNA interference [RNAi] and short interfering RNAs [siRNAs], Others), by Application (Monogenetic disorders, Multi-genetic disorders), by End User (Hospitals and Clinics, Academic and Research Institutes): Global Opportunity Analysis and Industry Forecast, 2022-2031
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