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2024

Creatine Kinase Market

Creatine Kinase Market Size, Share, Competitive Landscape and Trend Analysis Report, by Product, by Sample Type, by End User : Global Opportunity Analysis and Industry Forecast, 2024-2033

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Author's: Supriya Bhosale | Onkar Sumant
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Creatine Kinase Market Research, 2033

The global creatine kinase market size was valued at $332.0 million in 2023 and is projected to reach $900.1 million by 2033, growing at a CAGR of 10.6% from 2024 to 2033.

Creatine Kinase Market

Market Introduction and Overview

Creatine kinase (CK) is an enzyme that is predominantly found in the heart and skeletal muscles, with smaller quantities present in the brain. When muscle cells sustain damage, they release CK into the bloodstream. This enzyme acts as a catalyst, facilitating specific biochemical reactions. Elevated CK levels in the blood may indicate various forms of muscle damage or degeneration, both chronic and acute. CK test measures the amount of this enzyme in the bloodstream. There are three types of CK enzymes: CK-MM primarily in skeletal muscles, CK-MB mainly in heart muscle, and CK-BB predominantly in brain tissue.

Key Takeaways

  • The creatine kinase market study covers 20 countries. The research includes a segment analysis of each country in terms of value ($million) for the projected period from 2024 to 2033.
  • More than 1, 500 product literatures, industry releases, annual reports, and other such documents of major creatine kinase industry participants along with authentic industry journals, trade associations' releases, and government websites have been reviewed for generating high-value industry insights.
  • The study integrates high-quality data, professional opinions and analysis, and critical independent perspectives. The research approach intends to provide a balanced view of global markets and assist stakeholders in making informed decisions in order to achieve their most ambitious growth objectives.

Key Market Dynamics

The creatine kinase market growth is driven by the rising demand for diagnosing and monitoring various muscle-related conditions. CK tests are crucial in identifying muscular diseases and conditions such as rhabdomyolysis, aiding in timely intervention and management. In addition, the utility of CK tests extends to detecting muscular injuries resulting from accidents, intense exercise, or burns. Furthermore, CK tests are used to diagnose muscular inflammation (myositis) , including polymyositis and dermatomyositis. As CK levels can indicate heart damage, though less frequently used than troponin tests, they remain relevant in diagnosing heart attacks.

Limitations of creatine kinase (CK) include its non-specificity, as elevated levels can result from various conditions beyond muscular disorders. In addition, CK levels can be influenced by factors such as ethnicity, gender, age, and physical activity. CK testing may not always accurately reflect disease severity or progression, necessitating complementary diagnostic approaches. These factors are anticipated to hamper the creatine kinase market size in the coming years.

Creatine kinase (CK) presents opportunities in diagnosing and monitoring muscle diseases associated with muscle atrophy. Nowadays, CK testing is also associated with other diagnostic methods such as electromyography (EMG) and imaging studies, that provide a comprehensive approach to identifying the underlying causes of muscle atrophy. These factors are anticipated to have positive impact on the creatine kinase market forecast opportunities.

Analysis of the Creatine Kinase Industry

Musculoskeletal health poses a significant global challenge, affecting approximately 1.71 billion people as of July 2022. Conditions like low back pain, fractures, and osteoarthritis limit mobility, leading to early retirement and reduced well-being. The WHO's Rehabilitation 2030 initiative aims to address this by advocating for universal access to rehabilitation services.

Creatine kinase (CK) is useful in assessing muscle damage or injury associated with musculoskeletal conditions. Elevated levels of CK in the blood may indicate muscle breakdown due to conditions like muscular dystrophy, inflammatory myopathies, or traumatic injuries. Monitoring CK levels can aid in diagnosing and managing these conditions, guiding treatment strategies and assessing response to therapy. Therefore, CK measurements serve as a valuable tool in the comprehensive care and management of musculoskeletal health issues. These factors are predicted to drive the creatine kinase market share in the coming years.

The below data from the World Health Organization (WHO), 2022, highlights the urgent need for action to address musculoskeletal health globally

Musculoskeletal Condition

Global Prevalence

Years Lived with Disability (YLDs)

Low back pain

570 million

7.4% of global YLDs

Fractures

440 million

26 million YLDs

Osteoarthritis

528 million

19 million YLDs

Neck Pain

222 million

22 million YLDs

Amputations

180 million

5.5 million YLDs

Rheumatoid Arthritis

18 million

2.4 million YLDs

Gout

54 million

1.7 million YLDs

Other Musculoskeletal Conditions

453 million

38 million YLDs

Market Segmentation

The creatine kinase market is segmented into product, sample type, end user, and region. On the basis of product, the market is divided into instruments and reagents & kits. On the basis of sample type, the market is classified into blood, urine, and others. On the basis of end user, the market is divided into hospitals & clinics, diagnostic laboratories, and others. Region wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.

Country Market Outlook

In the U.S., Duchenne muscular dystrophy (DMD) affects nearly 1 in every 3, 500 male births, translating to about 250, 000 individuals living with some form of muscular dystrophy nationwide every year. Specifically, DMD accounts for fewer than 50, 000 cases in the country. The prevalence of DMD in the U.S. highlights its significant impact on affected individuals and their families, necessitating ongoing research and support for management and treatment. As the incidence of muscular dystrophy, including DMD, continues to be a concern globally and in the U.S., there is a rising need for diagnostic tools and therapeutic approaches to improve patient outcomes.

The rise in muscular dystrophy cases in the U.S. highlights the increasing demand for diagnostic tests like CK assays. These tests help physicians monitor disease progression, assess treatment effectiveness, and adjust management strategies accordingly. With advancements in medical technology and therapeutic options, early diagnosis facilitated by CK testing can lead to better management of symptoms and potentially slower disease progression in individuals with DMD. These factors are anticipated to drive the creatine kinase market growth.

Competitive Landscape

The major players driving the creatine kinase market share include Thermo Fisher Scientific Inc., BBI Solutions, Randox Laboratories Ltd., Novus Biologicals, Danaher, Boditech Med Inc., DiaSys Diagnostic Systems GmbH, Abbott, PerkinElmer Inc., and others.

Recent Key Strategies and Developments

  • In October 2023, a longitudinal retrospective study published in Journal Nature, surveyed 73 patients with spinal and bulbar muscular atrophy (SBMA) suggests that serum creatinine may not be a sensitive biomarker for disease progression. Despite previous indications linking creatinine levels to motor function in SBMA, this study found no significant decline in creatinine over a 36-month period, unlike other functional measures such as the SBMA functional rating scale and the 6-minute walk test. These findings highlight the need for further research to identify reliable biomarkers for tracking SBMA progression.
  • In September 2023, a recent pilot study in New York suggested that newborn screening for Duchenne muscular dystrophy (DMD) using creatine kinase-MM (CK-MM) levels in dried blood spots is feasible. Of the 36, 781 newborns screened, 42 tested positive and underwent next-generation sequencing, identifying five carriers of DMD. While the incidence mirrored previous findings, the study highlights the need to refine screening to reduce false positives.

Industry Trends and Creatine Kinase Market Opportunity Analysis

  • In January 2024, the research study published in the journal Nature, delving into mitochondrial creatine kinase 2 (CKMT2) sheds light on its potential as a prognostic marker and immunotherapeutic target across various cancers. Analyzing data from The Cancer Genome Atlas (TCGA) , researchers observed CKMT2's differential expression in different cancer types, with overexpression noted in four cancers and low expression in 14 others. Moreover, genetic variations and mutations in CKMT2 were linked to certain cancer types, providing insights into its role in tumorigenesis and progression.
  • In July 2023, the research study published by Bionews, Inc., highlighted various factors influencing the accuracy of creatine kinase-MM (CK-MM) blood tests used for Duchenne muscular dystrophy (DMD) screening in infants. Factors such as age at sample collection, gestational age, birth weight, sex, ethnicity, and seasonal temperature affect CK-MM levels, potentially leading to false-positive or false-negative results. The findings highlight the importance of considering these factors in newborn screening programs to ensure more reliable DMD diagnoses.

Key Sources Referred

  1. The Neuromuscular Disease Foundation

  2. National Institutes of Health (NIH)

  3. World Health Organization (WHO)

  4. Centers for Disease Control and Prevention

  5. WebMD LLC.

  6. National Library of Medicine

Key Benefits For Stakeholders

  • This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the creatine kinase market analysis from 2023 to 2033 to identify the prevailing creatine kinase market opportunities.
  • The market research is offered along with information related to key drivers, restraints, and opportunities.
  • Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
  • In-depth analysis of the creatine kinase market segmentation assists to determine the prevailing market opportunities.
  • Major countries in each region are mapped according to their revenue contribution to the global market.
  • Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.

Apart from the points mentioned above, the report includes the analysis of the regional as well as global creatine kinase market trends, key players, market segments, application areas, and market growth strategies.

Creatine Kinase Market Report Highlights

Aspects Details
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Market Size By 2033

USD 900.1 Million

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Growth Rate

CAGR of 10.6%

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Forecast period

2024 - 2033

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Report Pages

310

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By Product
  • Instruments
  • Reagents & Kits
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By Sample Type
  • Blood
  • Urine
  • Others
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By End User
  • Hospitals & Clinics
  • Diagnostic Laboratories
  • Others
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By Region
  • North America  (U.S., Canada, Mexico)
  • Europe  (Germany, Italy, Spain, UK, France, Rest of Europe)
  • Asia-Pacific  (China, Japan, India, South Korea, Australia, Rest of Asia-Pacific)
  • LAMEA  (Brazil, Saudi Arabia, UAE, South Africa, Rest of LAMEA)
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Key Market Players

Abbott, Diasys Diagnostic Systems GmbH., Randox Laboratories Ltd., Danaher, Novus Biologicals, BBI Solutions, PerkinElmer Inc., Thermo Fisher Scientific Inc., Boditech Med Inc.

Author Name(s) : Supriya Bhosale | Onkar Sumant
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Frequently Asked Questions?

The upcoming trends in the Creatine Kinase Market include point-of-care testing devices, growth in sports medicine and cardiac diagnostics, advancements in biomarker research, and increasing adoption in clinical laboratories for efficient patient management.

North America is the largest regional market for creatine kinase.

The global creatine kinase market is estimated to reach $900.1 million by 2033.

The top companies to hold the market share in creatine kinase are Thermo Fisher Scientific Inc., BBI Solutions, Randox Laboratories Ltd., Novus Biologicals, Danaher, Boditech Med Inc., DiaSys Diagnostic Systems GmbH, Abbott, and PerkinElmer Inc.

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Creatine Kinase Market

Global Opportunity Analysis and Industry Forecast, 2024-2033